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Increased plasma concentrations may cause increased side effects such as headache, fatigue, insomnia, and anxiety.

Drinking excessive amounts of grapefruit (approximately 1 L/day) increased drug concentrations 250. Increased drug exposure without effects on peak concentration may cause increased adverse events or toxicity evidenced by renal toxicity, hepatic toxicity, and increased immunosuppression. Per the Lipitor package insert, one study showed that drinking one glass of grapefruit juice (8 ounces) with atorvastatin resulted in an increased drug concentration of 37. 21 – 24įluvastatin (Lescol), pravastatin (Pravachol), rosuvastatin (Crestor)įibric acids, nicotinic acid, or bile acid sequestrantsĬyclosporine (Sandimmune, Neoral), tacrolimus (Prograf) Common drugs that interact with grapefruit. Increased plasma concentration may cause headaches, gastrointestinal complaints, hepatic inflammation, and myopathies (e.g., rhabdomyolysis). After you take a dose of Lipitor, your body. For grapefruit juice, this is more than 1.2 liters per day. 9Īmlodipine (Norvasc), diltiazem (Cardizem), verapamil (Calan)Ītorvastatin (Lipitor), lovastatin (Mevacor), simvastatin (Zocor) Grapefruit and grapefruit juice can interact with Lipitor when consumed in large quantities. Increased plasma concentration may lead to flushing, peripheral edema, headaches, tachycardia, symptomatic hypotension, and myocardial infarction in rare cases. 9, 20įelodipine (Plendil), nicardipine (Cardene), nifedipine (Procardia), nimodipine (Nimotop), nisoldipine (Sular) Increased plasma concentration of quinidine and disopyramide may be cardiotoxic causing torsades de pointes. 19ĭigoxin (Lanoxin), diltiazem (Cardizem), verapamil (Calan)

Increased plasma concentrations of amiodarone may cause thyroid or pulmonary toxicity, liver injury, QTc prolongation, proarrhythmic disorders, and bradycardia. Amiodarone (Cordarone), disopyramide (Norpace), quinidine